Flybe will axe its service between London City and Dublin on May 31.
The regional airline, which launched the route five months ago (see news, October 27), blamed weak passenger numbers for its decision.
Last week, Flybe announced it will suspend its London Southend to Dublin route (see news, March 20) and, last month, it cancelled its London City to Inverness service (see news, January 6).
Paul Simmons, Flybe CCO, told City AM: "Despite our competitive pricing structure, overall passenger numbers are below our projections and there are no signs of this situation changing, which has led to us taking this decision.
"Flybe has a disciplined approach to the routes it operates, which means we continually review our network to ensure that we offer the right choice of destinations for our customers."
Graham Smith