Virgin Atlantic Flying Club members who stay at Virgin Hotels Chicago will be awarded 1,000 miles per stay plus double bonus miles.
Gold members will also receive a free breakfast and room upgrade, while Silver members will receive a room upgrade.
The offer runs until April 30, although Flying Club members based in the UK will qualify for bonus miles until July 31.
In order to qualify, members must make their reservation either by entering their Flying Club number at virginhotels.com or by phoning +1 312 940 4300.
Virgin Hotels opened its first property in Chicago last month (see news, January 16). The brand plans to open hotels in Nashville in autumn 2016 and New York in summer 2017.
Alan Lias, Virgin Atlantic's worldwide head of loyalty and ancillary revenue development, said: "Loyal Virgin lovers can kick back and relax knowing they're earning Flying Club bonus miles while they eat, sleep and enjoy themselves in the new Virgin Hotels Chicago property."
Doug Carrillo, Virgin Hotels' vice president of sales and marketing, added: "We look forward to the day when we can announce a UK property, a location we’re actively pursuing."
Subscribers to the UK edition of Business Traveller can now earn up to 2,000 Flying Club miles with Virgin Atlantic. Click here for more information.