Emirates will upgrade one of its three Perth services to an A380 on May 1.
The Gulf carrier will remove a B777-300ER aircraft from the route and replace it with a superjumbo, resulting in an additional 136 seats per flight, or an extra 1,904 seats per week.
The A380 will be rostered onto flight EK420 departing Dubai at 0255 and arriving at Perth International airport at 1735 the same day. Return flight EK421 will take-off from Perth at 2210 and land in Dubai at 0525 the next day.
Barry Brown, Emirates' divisional senior vice-president, said: "For business and leisure travellers, the Dubai-Perth route is a popular choice and our new Emirates A380 service will be instrumental in helping the airline meet this growing passenger demand as well as deliver substantial economic benefits through travel connections and inbound seats.
"Australian customers are extremely important to Emirates, and the deployment of a fifth Emirates A380 service to the country in association with Qantas demonstrates this further."
The A380 on the Perth route will be in a three-class configuration, with 401 seats in economy, 76 fully-flat seats in business and 14 suites in first class.
Last month, Emirates announced it will launch a third daily A380 service to New York JFK in March (see news, November 6).