Emirates will deploy an A380 to Kuwait from July.
The Gulf carrier will upgrade the Boeing 777-200LR that currently operates flights EK0857 and EK0858 to a superjumbo on July 16.
The A380 on the route will offer 14 First Class Private Suites, 76 flat-bed seats in Business and 399 seats in Economy (click here to view a seatplan).
Emirates currently serves the Dubai to Kuwait route five-times daily using both Boeing and Airbus aircraft.
Kuwait is only the second destination in the Middle East to be served by the Emirates A380, after the Kingdom of Saudi Arabia.
Sheikh Majid Al Mualla, Emirates' Divisional Senior Vice President, Commercial Operations, Centre, said: "This is a tremendous opportunity for customers travelling to and from Kuwait to enjoy the pride of the Emirates fleet.
"We have 47 A380s which we deploy all over the world from LA to Auckland, but the experience continues to generate excitement and fascination amongst our passengers and those who come to airports just to catch a glimpse of this magnificent aircraft."
Emirates currently operates its A380 to 28 of its 142 global destinations.