Colombian airline Avianca will launch a direct service between London Heathrow and Bogota this summer.
The route was announced yesterday by Deputy Prime Minister Nick Clegg during a trade visit to Colombia.
It will be the only direct flight between the UK and Colombia and is expected to open in July.
According to the British embassy in Colombia, more than 20,000 British citizens have flown to the country during the past year.
Avianca's new direct route is expected to have a "significant impact on tourism and business", said Clegg's office.