Ryanair will launch a new service between Manchester and Bologna in April.
The budget carrier will fly the route three times weekly, on Tuesdays, Thursdays and Saturdays.
The service begins on April 1.
Ryanair spokesperson Maria Macken said: "Ryanair is delighted to announce a new route from Manchester to Bologna in northern Italy which will operate three times weekly.
"Next summer Ryanair is offering passengers in Manchester the choice of 33 top destinations including three Italian routes to Milan Bergamo and Rome as well as the new route to Bologna."
Last month, it emerged that Ryanair is adopting a change of tack by moving into main airports in order to tap lucrative corporate travel (see news, November 28).