Flybe is axeing 30 routes from its network in the new year, including 14 that operate only during the summer.
The regional airline will run 150 services during the 2014 summer season between March 30 and October 25.
The year-round routes to be cut include Glasgow to Shannon on January 5; Bristol to Jersey on January 7; East Midlands to Paris Charles de Gaulle on January 13; Belfast to Paris CDG, Hanover to Southampton, Leeds Bradford to Southampton, Cardiff to Glasgow, Cardiff to Paris CDG, and Glasgow to Paris CDG on January 19; and Exeter to Newcastle on March 28.
However, between February 20 and 24 the carrier will again operate its Cardiff and Glasgow to Paris CDG routes to accommodate those travelling to Six Nations rugby matches.
The 14 seasonal summer routes to be axed include Exeter and Southampton to Barcelona; Bristol to Isle Of Man; Edinburgh to Knock and Newquay to Norwich.
Flybe had already announced the end of all six services from Gatwick from March 30, 2014, after the airline sold all of its slots at the airport to Easyjet.
Paul Simmons, Flybe's chief commercial officer, said: "We recently announced that we would be reconfiguring our route network as part of a carefully planned strategy to optimise our operations.
"We have since taken a long hard look at all the routes we fly to make sure that our new schedule is what our customers really want and that they operate at the best possible times for everyone.
"The extent of our confirmed regional network, with more than 150 routes on sale for next summer, means that no other airline has the regional and onward international connectivity offered by Flybe."
The news comes less than a month after Flybe announced 500 job cuts across its business, the second set of mass redundancies the airline has announced this year (see news, November 11).