Eastern Airways will begin operating flights between the French cities of Lorient and Lyon next month.
The UK-based airline, which is based at Humberside airport, will offer two flights per day as well as one Sunday service in both directions. The route is scheduled to begin on January 5.
Weekday services will depart from Lorient at 0620 and 1645, arriving in Lyon at 0810 and 1835. Flights will leave Lyon on weekdays at 0840 and 1905, landing in Lorient at 1030 and 2055.
Sunday flights will depart Lorient at 1645, arriving in Lyon at 1835, with return flights leaving at 1905, arriving in Lorient at 2055.
Eastern Airways has been running domestic flights in France since 2010 with a base at Dijon flying to Bordeaux and Toulouse.
Kay Ryan, Eastern Airways' commercial director, said: "We are delighted to be awarded this important contract to operate the Lorient South Brittany–Lyon Saint Exupery route.
"This is a major step forward in the development of our domestic services in France. It is built on the back of the solid foundations that we put in place in Dijon, setting up a base and domestic services in 2010 to serve the Burgundy region."