Scandinavian Airlines is launching a five-weekly service between Copenhagen and Humberside Airport on Monday.
The direct, year-round route will operate on Mondays, Wednesdays, Thursdays, Fridays and Sundays.
Weekday flights depart Copenhagen at 1810 and arrive in Humberside at 1845, with the return service leaving Humberside at 1915 and landing in Copenhagen at 2150.
The Sunday services depart Copenhagen at 1350 and Humberside at 1455.
SAS will deploy a 50-seater CRJ200 aircraft on the route and fares start from £103 one way, including taxes and charges.
Hans Dyhrfort, SAS's regional general manager Western Europe, said: "This is a major milestone for SAS, as we will start providing the only non-stop, direct service to Scandinavia from the Humber, Lincolnshire and Yorkshire region.
"With the area on its way to becoming the renewable energy capital of the UK, the Humber region is an important northern hub and area of development for SAS.
"We are pleased to offer both leisure and business passengers the choice and flexibility to fly direct from Humberside to Copenhagen or onwards to many other destinations in Scandinavia and Northern Europe."
In August, SAS and Singapore Airlines announced the expansion of their codeshare agreement to cover more destinations in Europe, south-east Asia, Australia and New Zealand (see news, August 30).