John Lewis will open its first air-side branch at Heathrow's new Terminal 2 next year.
The British retailer's 335 sqm shop will be located on the top floor of the departure lounge and will be immediately visible to passengers as they exit security.
John Lewis Heathrow will sell "the best of home, fashion, gifting and seasonal ranges".
Andy Street, John Lewis' managing director, said: "This new opening is a huge and exciting step forward in developing our international strategy, giving us access to one of the most concentrated, valuable and influential markets in the world.
"We recently made clear our ambition to further develop our online presence internationally in addition to increasing our international wholesale business. This opportunity at Heathrow perfectly complements and enhances these initiatives."
Terminal 2 will be officially named in honour of Queen Elizabeth II when it opens next year (see online news, June 17).
The £2.5 billion facility, which is scheduled to open its doors on June 4, will be called Terminal 2: The Queen's Terminal.
The monarch opened the original Terminal 2 in 1955, almost 60 years ago and two years after her coronation.
Muriel Zingraff-Shariff, Heathrow's retail director, said: "We're excited to bring John Lewis to Heathrow and share this much-loved British retail brand with our international audience."